Ncor2 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comNcor2 Polyclonal Antibody for Mouse(Mus musculus)

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Ncor2 (Gene name),

Nuclear receptor corepressor 2 (Protein name ), NCOR2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ncor2(Smrt);

Protein name:

Nuclear receptor corepressor 2(N-CoR2);

Alternative:

T3 receptor-associating factor(TRAC);Silencing mediator of retinoic acid and thyroid hormone receptor(SMRT;SMRTe);Thyroid-, retinoic-acid-receptor-associated corepressor;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts with HDAC10, BCL6 and MINT. Interacts with ATXN1L. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity (By similarity). Interacts with CBFA2T3, C1D and HDAC7. Interacts with NR4A2; the interaction increases in the absence of PITX3.

Function:

Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

2472

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HAWDEEPKPL | LCSQYETLSD | SE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.278646

SMR:

Q9WU42

STRING:

10090.ENSMUSP00000107033

String:

Q9WU42

Pfam:

PF00249

KEGG:

mmu:20602

Uniprot:

Q9WU42

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ELISA Kit for Mouse N-CoR2

Cat.:

E0334h

Price:

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Mouse N-CoR2

Cat.:

E0334m

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MSDS:

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Packing:

96T

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CLIA Kit for Mouse N-CoR2

Cat.:

U0334m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Mouse N-CoR2

Cat.:

U0334h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Mouse N-CoR2

Cat.:

P0334Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse N-CoR2

Cat.:

P0334Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse N-CoR2

Protein for Mouse N-CoR2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Unique forms of human and mouse nuclear receptor corepressor SMRT."
Ordentlich P. , Downes M. , Xie W. , Genin A. , Spinner N.B. , Evans R.M.
Proc. Natl. Acad. Sci. U.S.A.96:2639-2644(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA)
tissue: Brain.
tissue: Spleen.
2.

"SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor."
Park E.J. , Schroen D.J. , Yang M. , Li H. , Li L. , Chen J.D.
Proc. Natl. Acad. Sci. U.S.A.96:3519-3524(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
tissue: Embryo.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex."
Zamir I. , Dawson J. , Lavinsky R.M. , Glass C.K. , Rosenfeld M.G. , Lazar M.A.
Proc. Natl. Acad. Sci. U.S.A.94:14400-14405(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C1D
5.

"Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression."
Kao H.-Y. , Downes M. , Ordentlich P. , Evans R.M.
Genes Dev.14:55-66(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC7
6.

"ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
Amann J.M. , Nip J. , Strom D.K. , Lutterbach B. , Harada H. , Lenny N. , Downing J.R. , Meyers S. , Hiebert S.W.
Mol. Cell. Biol.21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBFA2T3
7.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-550 AND SER-2215;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
8.

"Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression."
Jacobs F.M. , van Erp S. , van der Linden A.J. , von Oerthel L. , Burbach J.P. , Smidt M.P.
Development136:531-540(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NR4A2
9.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2181;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1983;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
11.

"Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms."
Huang C. , Hatzi K. , Melnick A.
Nat. Immunol.14:380-388(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;INTERACTION WITH BCL6

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